Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study

Inclusion Criteria: 1. Signed informed consent before any study-related activities, 2. Male or female aged 18-70 years, 3. Type 1 diabetes mellitus (T1D) duration more than six months 4. Treatment with multiple daily injections (MDI) for at least three months before screening visit; stable insulin dose for the last one month, 5. No use of any oral anti-diabetics, any other form of insulin other than mentioned in the protocol, or any other type of injections such as glucagon-like-peptide-1 (GLP-1) analogs, pramlintide or insulin/GLP-1 analog combinations, 6. A1c between 6.5 to 10%, 7. Willingness to routinely collect at least two blood glucose measurements per day needed to calibrate the CGM. Beyond the calibrations, patients may use CGM for necessary action without having to confirm with fingersticks self-monitoring blood glucose (SMBG), as approved by the Food and Drug Administration (FDA), 8. BMI ≤35 kg/m2, 9. Ability and willingness to adhere to the protocol including clinical and phone visits and 4-week-long CGM wear, 10. Using insulin glargine or insulin degludec as basal insulin, 11. Able to use and understand CGM data, 12. Willing to complete phone and clinic visits, 13. Patients who eat three main meals in a day (breakfast, lunch, and dinner), 14. Patients who use insulin-carb ratio for bolus, 15. Ability to speak, read, and write English, and 16. Patients prandial insulin need must be \<18 units per meal Exclusion Criteria: 1. Use of any other diabetic medication other than allowed in the protocol, 2. Pregnant or intention to become pregnant during the study, or not using adequate birth control methods, 3. Severe unexplained hypoglycemia requiring emergency treatment in the previous three months, 4. Use of systemic or inhaled corticosteroids, 5. History of hemoglobinopathies, 6. Diagnosis of anemia, 7. Post-renal transplantation, currently undergoing dialysis, creatinine \>2.0 mg/dl or a calculated creatinine clearance of \<50 mL/min, 8. Advanced or unstable retinopathy needing laser procedure or vitrectomy, 9. History of pancreatitis, 10. Extensive skin changes/diseases that inhibit wearing a sensor on normal skin, 11. Known allergy to adhesives, 12. Known allergy to study medication, 13. Participation in another investigational study protocol within 30 days before enrollment, 14. Known chronic obstructive pulmonary disease, pulmonary hypertension, asthma, pulmonary fibrosis, or any chronic pulmonary infection, or any systemic disease that primarily affects the lungs. History of any pulmonary nodule will be excluded to participate in the study, 15. Active smokers, 16. Marijuana users, 17. Insulin pump users, 18. Using insulin detemir or NPH as basal insulin, and 19. Any other condition, as determined by the investigator, which could make the subject unsuitable for the trial, impairs the subject's suitability for the trial, or impairs the validity of the informed consent -