Study of Prognostic Biomarkers of Survival at 6 Months for Patients Treated With Bevacizumab Glioblastomas in First Relapse After Failure of Radiochemotherapy

Inclusion Criteria: * Patients, between 18 and 88 years, with glioblastoma (histologically proven) in first relapse after conventional treatment by surgery and temozolomide and radiotherapy * Biological Criteria * Polymorphonuclear neutrophils\> 1500 / mm3 * Plates\> 100,000 / mm3 * SGOT-SGPT \<5 at the upper limit of normal (ULN) * Bilirubin \<1.5 x ULN * Creatinine \<1.5 LSN and creatinine clearance * Proteinuria \<1 g / 24 hours * Patient with health insurance * Consent signed by the patient if he is lucid, or failing that by the person of trust Exclusion Criteria: * Patients who can not benefit from bevacizumab for the following reasons: * Symptomatic cerebral or tumor hemorrhage * Karnofsky Index less than 50% or * Patients already treated with an antiangiogenic molecule or Gliadel (diagnosis and recurrence). * Coagulation disorders in case of injectable treatment (especially for avastin), * Contraindications known to the MRI: Pace Makers, foreign bodies intraocular, electrodes ... * Uncontrolled severe concomitant pathology, including another evolving cancer (with the exception of operative cutaneous tumors, in situ cancer of the cervix or breast treated). * Uncontrolled Infection * Uncontrolled hypertension (PAS\> 160 mm Hg) despite optimized treatment * Coronary artery disease or unstable arterial disease. Evolutionary aneurysm. * Myocardial infarction dating from less than 6 months. * Peripheral arterial or cerebrovascular accident occurring less than 6 months. * Heart Failure\> grade II NYHA * Hemorrhagic Disease (Hemophilia, Willebrandt ...) * Nephrotic syndrome with proteinuria\> 2 g / 24 h * History of haemoptysis dating less than 1 month. * Pulmonary embolism dating less than 1 month. * Surgical intervention (other than craniotomy or stereotactic biopsy) dating less than one month or essential and predictable surgery. * History of digestive fistula or intestinal perforation with resolution less than 6 months. * Hypersensitivity to bevacizumab or to any of the excipients mentioned in Composition. * Hypersensitivity to Chinese hamster ovary (CHO) cells or to other human or humanized recombinant antibodies. * Severe Myelosuppression * Pregnant or nursing. Contraception should be prescribed if necessary during treatment. * Persons deprived of liberty or placed under safeguard of justice (guardianship or curatorship), * Subject involved in another search including an exclusion period still in progress at pre-inclusion * Patient refusing to participate in the study