General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
• Specific objectives: * To test the usefulness of skin laser Doppler flowmetry monitoring (LDPM) in the non-invasive evaluation of endothelium-dependent microvascular reactivity during CPB in children. * To investigate whether skin LDPM could be proposed as a clinical monitoring of tissue perfusion during CPB in pediatric cardiac surgery. * To investigate the effects of different anesthetic agents on microvascular reactivity during CPB. * To investigate the effects of cardiovascular and vasoactive drugs used during CPB on microvascular reactivity. * To evaluate the correlation of microcirculatory alterations observed during CPB with classical markers of tissue perfusion and oxygenation, including plasma lactate levels. * To evaluate the correlation of microcirculatory alterations observed during CPB with markers of systemic inflammation, including pro- and anti-inflammatory cytokines. * To evaluate the correlation of microcirculatory alterations observed during CPB with the plasma bioavailability of nitric oxide.
Study Type
OBSERVATIONAL
Enrollment
100
National Institute of Cardiology, Ministry of Health, Brazil
Rio de Janeiro, Brazil
Microcirculatory alterations during cardiopulmonary bypass
Evaluation of the alterations of microcirculatory parameters and tissue perfusion during cardiopulmonary bypass in children submitted to cardiac corrective surgery for congenital heart defects
Time frame: december 2019
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