The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU) patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from Pulsion medical system PiCCO2 ® monitoring), including preload dependency evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU) patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from Pulsion medical system PiCCO2 ® monitoring), including preload dependency evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.
Study Type
OBSERVATIONAL
Enrollment
52
Hôpital Cardiologique Louis Pradel
Lyon, Auvergne-Rhône-Alpes, France
RECRUITINGMatthias Jacquet-Lagreze
Lyon, Rhône, France
NOT_YET_RECRUITINGplasmatic protein concentration variation
Two sample of plasmatic protein before and after a fluid removal will be performed. The variation of the protein concentration (computed as the difference between final and baseline value divided by the baseline value expressed in %) will be the index test to diagnose a decrease of cardiac output of more than 15 % due to the fluid removal.
Time frame: 1 hour
Plasmatic protein concentration in patient with preload dependency before fluid removal
hemoconcentration will be evaluated in the subgroup of preload dependent patients
Time frame: 1 hour
Central venous pressure (CVP)
CVP will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
Time frame: 1 hour
Global end diastolic volume (GEDV)
GEDV, calculated with transpulmonary thermodilution will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
Time frame: 1 hour
Extravascular lung water (EVLW)
EVLW, calculated with transpulmonary thermodilution will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
Time frame: 1 hour
hemoconcentration evaluated with hemoglobin variation
hemoconcentration evaluated with hemoglobin variation will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
Time frame: 1 hour
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