Prospective observational multicenter study in European ICUs. All patients admitted to the ICU for probable or confirmed Acute encephalitis (2013 IDSA - Infectious Disease Society of America criteria) will be included. Factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.
Primary objective : evaluate the correlation between mRs score and the baseline characteristics Functional outcomes will be evaluated using the modified Rankin score (mRS) score, which is one of the most frequently used scores in acute neurological diseases \[18\]. A poor outcome will be defined by a mRS score \> 2 (functional dependence or death). The investigator usually evaluates this score if the patient is still in the hospital 90 days after admission. Patients discharged from hospital within 90 days following ICU admission without major disability (mRS 0, 1 or 2) are considered to have a good outcome. Patients discharged within 90 days with a disability will be classified for the study according to the latest available data. Patients will not be contacted directly by the investigator for the study purposes. Secondary objectives : To identify additional prognosis factors : the clinical, radiological, biological and neurophysiological factors associated with poor outcome for patients admitted to the ICU with AE * Day 28 mortality, in-ICU mortality, in-hospital mortality * Major systemic complications (septic shock, hyponatremia, nosocomial pneumonia, catheter-related BSI, overt gastroenteral bleeding, pulmonary embolism) * Major intracranial complications during ICU stay * Status epilepticus * Brain death * Empyema/cerebral abscess * Cerebral ischemia * Intracranial bleeding * ICP monitoring * Neurosurgery The cause of death will be categorized into 2 categories: * Systemic causes (cardiovascular failure, MOF) * Neurological cause (Diffuse neurologic injury or withdrawal of care)
Study Type
OBSERVATIONAL
Enrollment
596
Not applicable, non-interventional study
Modified Rankin scale score
The modified Rankin Scale (mRS) is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It has become the most widely used clinical outcome measure for stroke clinical trials.
Time frame: Day 90
Mortality at Day 28
Rate of death at day 28
Time frame: Day 28
Systematic complications
Septic shock, hyponatremia
Time frame: Day 90
Intracranial complications
Documented seizures, status epilepticus, Diffuse cerebral edema, herniation, Ischemia, cerebral hemorrhage
Time frame: Day 90
Intracranial pressure monitoring
List of all available methods of intracranial pressure monitoring used in study sites and their outcome
Time frame: Day 90
Neurosurgery
Monitoring of neurosurgery to identify additional prognosis factors
Time frame: Day 90
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Medical University of Innsbruck
Innsbruck, Austria
Centre Hospitalier d'Angoulême
Angoulême, France
Centre Hospitalier Annecy Genevois
Annecy, France
Hôpital Victor Dupouy
Argenteuil, France
Hôpital Ambroise Paré
Boulogne-Billancourt, France
CHU Brest
Brest, France
Hôpital Pierre Wertheimer
Bron, France
Centre Hospitalier René Dubos
Cergy-Pontoise, France
CH de Charlesville-Mézières
Charleville-Mézières, France
Les Hôpitaux de Chartres
Chartres, France
...and 55 more locations