The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
8
Palm stearin
Water
Fish Oil, Omega 3 PUFA
Change in muscle protein fractional synthetic rate
Measurement of FSR at baseline and post intervention
Time frame: 3 hours post protein drink
whole body postprandial insulin sensitivity
Glucose and insulin area under the curves (AUC) in response to the milk protein and glucose ingestion will be measured
Time frame: Baseline and every 15mins for 7 hours
Whole body and skeletal muscle fat oxidation
D31palmitate plasma enrichment and incorporation into skeletal muscle lipids
Time frame: Baseline and every 15mins for 7 hours
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