Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?

Inclusion Criteria: * Men and non-pregnant women who have had ultrasound and radiographic assessments in the Knee Pain in the Community study o Premenopausal women will need to be on an acceptable contraceptive method * Aged 40-95 years * Knee pain between 4-8 on the NRS * Knee osteoarthritis - defined as knee pain plus radiographic changes, based on previous questionnaire responses and radiographic findings * Knee pain: individuals with knee pain in and around the knee on most days for at least a month. * Radiographic changes: definite joint space narrowing and definite osteophytes (each scoring two or more on the Nottingham Line Drawing Atlas) in the tibiofemoral and/or patellofemoral compartments * Predominantly neuropathic or inflammatory phenotypes based on previous questionnaire responses (not current status) * Predominantly neuropathic phenotype: painDETECT Questionnaire (PDQ) \> 13 and synovial hypertrophy (SH) \<4 mm * Predominantly inflammatory phenotype: SH \> 4 mm and PDQ \< 13 * If we cannot recruit enough people with the above thresholds, we will base recruitment on the overall distribution of PDQ and SH scores from the population. The third tertile of PDQ and the first tertile of SH for neuropathic and the first tertile of PDQ and the third tertile of SH for inflammatory phenotypes. Exclusion Criteria: * Inability to give informed consent * Daily use of oral NSAIDs for the last two weeks * Prior use of Ibuprofen gel or Zacin on the affected knee(s) * Terminal or untreated major mental illness * Pregnancy or breastfeeding * Hypersensitivity or allergy to topical NSAIDs, capsaicin, or other ingredients in the preparations. This includes individuals that experience attacks of asthma, urticaria, or acute rhinitis that are precipitated by NSAIDs * Current treatment for stomach or duodenal ulcers * Total joint replacement of affected joint * Renal failure * Taking anticoagulants