Efficacy and Safety of Jiedu Tongluo Granules for Post-stroke Depression

Inclusion Criteria: * Clinical diagnosis of stroke, with neurological deficits symptoms; * Clinical diagnosis of depression, according to the Diagnostic and Statistical Manual of Mental Disorders-IV （DSM-IV）or Chinese Classification and Diagnostic Criteria of Mental Disorders-3(CCMD-3), the score is between 7 to 24 by 17-item Hamilton Depression; * Age of 45 to 80 years old; * The patient is conscious, cooperation, without aphasia and severe cognitive impairment after acute phase of stroke; * Without psychiatric disease history or family history of psychosis before stroke; * No hormones and psychotropic drugs were used within 1 month before enrollment; * capacity to provide written consent. Exclusion Criteria: * With brain organic disease such as brain tumors; * Had a history of psychiatric illness or depression before stroke; * Combined with severe liver, kidney, hematopoietic system disorder; * Poor glycemic control and insulin-dependent diabetes; * Participate in any clinical trial or taking antidepressant treatment 1 month prior to baseline; * Pregnant or breast feeding; * History of sensitivity to Chinese medicine ingredients.