Intrauterine Misoprostol Versus Intravenous Oxytocin Infusion During Cesarean Delivery

Assiut University240 enrolled

Overview

Bleeding is still the major cause of mortality and morbidity in postpartum period. World health organization has reported 585000 deaths for pregnancy each year. Twenty five percent of cases die from post-partum bleeding. Mean amount of blood lost is 500 ml during normal vaginal delivery, 1000 ml in cesarean section, and 3500 ml during cesarean section with emergency hysterectomy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

240

Conditions

Post Partum Hemorrhage

Interventions

MisoprostolDRUG

intrauterine tablets

OxytocinDRUG

intravenous

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: 1-Uncomplicated pregnancy, 2-Had no hypersensitivity or contraindications to prostaglandins. 3-Had no history of coagulopathy. 4-Accepting to participate in the study. Exclusion Criteria: \\1-women with anemia (Haemoglobin \<8 gram ). 2 placental abnormality (e.g placenta previa,placenta abruption ) 3. History of complications at previous pregnancy especially postpartum hemorrhage. 4- Maternal hypertension , current or previous history of heart disease ,liver ,Renal disorders or known coagulopathy

Locations (1)

Assiut Faculty of Medicine

Asyut, Egypt

Outcomes

Primary Outcomes

amount of intraoperative blood loss

Time frame: 30 minutes

Data from ClinicalTrials.gov

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