This prospective double-blind placebo-controlled randomized clinical trial will be conducted at Ain-Shams University Maternity Hospital from April 2017 till December 2017. Group 1 women, candidates for cesarean section, will receive preoperative rectal 400 microgram of misoprostol, and Group 2 women will receive postoperative rectal 400 microgram of misoprostol. 2017\. 120 women candidate foe elective cesarean section will receive preoperative sublingual 400 microgram of misoprostol, and another 120 women will receive postoperative sublingual 400 microgram of misoprostol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
300
Cytotec
Placebo tablet similar in shape, odour and consistency to misoprostol tablet.
Ain Shams University
Cairo, Egypt
Neonatal outcome
measured by APGAR score at 5 minutes
Time frame: 5 minutes
NICU admission
Number of neonates admitted to NICU within 24 hours.
Time frame: 24 hours
amount of blood loss
Time frame: 24 hours
Postpartum hemorrhage
Time frame: 24 hours
Need for extra uterotonics
Time frame: 24 hours
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