About 5% of breast cancers are metastatic at diagnosis and 20-30% of localized breast cancer become secondarily metastatic.Thanks to recent therapeutic advances, the median survival ranges between 12 months in 1970 and 18 to 24 months in 2000. However, patients suffer from many detrimental symptoms such as fatigue, pain related to treatment and metastasis. The physical, biological, psychological and clinical benefits of physical activity (PA) during treatment in patients with localized breast cancer have been widely demonstrated. Numerous studies investigated the effect of PA in non-metastatic breast cancer, but to our knowledge, only four interventional studies worldwide focused on the implementation of PA in patients with metastatic breast cancer.It seems appropriate to investigate the feasibility of PA intervention with patients with metastatic breast cancer to see if the observed effects in localized breast cancer are confirmed in metastatic breast cancer population. The ABLE study is an interventional cohort designed to assess the feasibility of a 6-month adapted physical activity intervention, performed under real life conditions in patients with metastatic breast cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
51
The program is individualized according to age, fitness level, place of residence, access to adapted specific training group or associations, PA preferences and wishes of each participant. Patients are informed of the recommendations in terms of PA, and the target of 150min per week in order to maintain health benefits. Patients are asked to walk at least 30 minutes per day and increase their activities into daily routine. Several individual strategies are established with the patients to attain their objectives and increase their daily life PA. Withings® PA trackers have been used to provide an incentive effect to increase PA, to measure the number of steps per day and make people think about their PA. Patients wore a Withings Go® wristband PA tracker throughout the whole study and had in real time a feedback on their number of steps per day. A 7 mL blood sample is collected at baseline (D1) and at the end of the 6-month study (M6) for the biological study.
Centre Léon Bérard
Lyon, France
Proportion of patients achieving the physical activity program recommendations
150 min per week of moderate PA assessed by the IPAQ
Time frame: 6 months
Variation of oxidative stress
7mL blood sample is collected at baseline and at the end of the study
Time frame: 6 months
Investigate the effects of a PA intervention on fitness level
IPAQ in MET-min per week
Time frame: 6 months
Investigate the effects of a PA intervention on fitness level
6-min walk test in meters
Time frame: 6 months
Investigate the effects of a PA intervention on fitness level
VO2 peak in ml per kg per minute
Time frame: 6 months
Investigate the effects of a PA intervention on fitness level
strength test in kilograms
Time frame: 6 months
Investigate the effects of a PA intervention on quality of life
EORTC QLQ-C30
Time frame: 6 months
Investigate the effects of a PA intervention on quality of life
BR-23
Time frame: 6 months
Investigate the effects of a PA intervention on fatigue
PIPER scale
Time frame: 6 months
Investigate the effects of a PA intervention on social deprivation
EPICES score
Time frame: 6 months
Investigate the barriers and facilitators of adherence to a PA program
Specific questionnaire
Time frame: 6 months
Investigate the effects of a PA intervention on changes in anthropometrics
BMI in kilograms per m²
Time frame: 6 months
Investigate the effects of a PA intervention on changes in anthropometrics
waist circumference in centimeters
Time frame: 6 months
Investigate the effects of a PA intervention on changes in anthropometrics
Weight in kilograms
Time frame: 6 months
Investigate the effects of a PA intervention on changes in anthropometrics
Hip circumference in centimeters
Time frame: 6 months
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