Evaluating MMPs in Burns

University of Florida8 enrolled

Overview

The objective of this study is to determine whether our chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.

This is an observational pilot study of patients treated at UF Health Shands Burn Center adult service. This is a study to determine the predictive value of quantifying concentrations of specific MMPs. Coupling this with a specialized collection sample collection system and a calibrated fluorimetry allows for the rapid assessment of MMP concentrations. This assay has been validated as a predictor of failed wound healing in a published clinical study involving chronic open wounds.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Burns Thermal Burn Thermal Injury

Interventions

GraftPROCEDURE

Autogenous skin grafting is the only definitive treatment for the full thickness burn injuries, and thus represents the centerpiece of modern burn care.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 98 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * Admitted with acute burns injuries (flame, contact or scald) requiring at least one surgical excision and grafting operation will be considered for inclusion * Burn injury less than one week old Exclusion Criteria: * Electrical, chemical or cold-induced burn injury * Total body surface area burn \>50 % * Pre injury diagnosis of chronic renal insufficiency, liver failure, refusal to accept blood transfusion or withdrawal of care within three days of admission will also be exclusion criteria * Patients not expected to survive * Patients presenting with re-injury to previously burned and treated areas. * Patients who present after receiving burn excision surgery out an outside facility for the current acute injury

Locations (2)

UF Health Cancer Hospital

Gainesville, Florida, United States

UF Health Shands at the University of Florida

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Predictability of graft take

Determine whether chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.

Time frame: 2 years

Secondary Outcomes

Wound healing

Assess the predictive value of serial MMP assays in identifying wounds transitioning from likely-to-fail to likely-to-succeed

Time frame: 2 years

Data from ClinicalTrials.gov

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