Accelerated Vaccination Schedule Against Hepatitis B Virus With Combined Hepatitis A and B Vaccine Among Hemodialysis Patients

Benha University114 enrolled

Overview

The aim of this study is to examine the result of seroprotection using the accelerated vaccination schedule in vaccination of hemodialysis patient through using combined hepatitis A and B vaccine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

114

Conditions

Hepatitis B Hemodialysis Complication

Interventions

Hepatitis B recombinant DNA vaccineDRUG

Hepatitis B recombinant DNA vaccine

Combined hepatitis A and B vaccineDRUG

Combined hepatitis A and B vaccine given to the patients

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age was above 18 years * Hemodialysis patient * All patients had undetectable hepatitis B virus surface antigen and antibody Exclusion Criteria: * A positive serum hepatitis B virus surface antigen and antibody * patient received a previous course of hepatitis B virus vaccine

Outcomes

Primary Outcomes

Hepatitis B virus Seroprotection after one month

Hepatitis B virus surface antibodies titer after one month

Time frame: one month after third dose of the vaccine

Hepatitis B virus Seroprotection after three months

Hepatitis B virus surface antibodies titer after three month

Time frame: three months after third dose of the vaccine

Secondary Outcomes

Fever

The proportion of fever among patients in both arms

Time frame: 4 Days after each vaccination dose

Pain scale

Visual pain scale for pain from injection

Time frame: 1 Hour after each vaccination dose

Data from ClinicalTrials.gov

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