The Liver Health Study for Patients with NAFLD

For Phase I: Any patient scheduled to undergo bariatric surgery or a liver biopsy to diagnose nonalcoholic fatty liver disease. For Phase II: Only subjects who have had a diagnosis of nonalcoholic fatty liver disease and completed Phase I (and no subjects who have undergone bariatric surgery) Inclusion Criteria: 1. Men and women (pre and post-menopausal) 2. Overweight/obese with BMI ≥ 25.9 or \< 50.0 kg/m2 3. Characteristics of the metabolic syndrome, pre-diabetes (fasting glucose 100-125 mg/dL or 2h glucose 140-200 mg/dL) or diabetes type 2, or undergoing bariatric surgery 4. 22-65 years of age 5. Sedentary, \< 60 minutes per week of structured physical activity 6. Alcohol intake\< 20 g/d Exclusion Criteria: 1. Having undergone bariatric surgery. 2. Acute disease or advanced cardiac or renal disease, anticoagulation therapy, or any severe co-morbid condition limiting life expectancy \< 1 years 3. Other causes of hepatitis including hepatitis B \& C, autoimmune hepatitis, hemochromatosis, celiac disease, Wilson's disease, alpha-1-antitrypsin deficiency, medication-induced hepatitis, any clinical or biochemical evidence of decompensated liver disease 4. Use of steroids or other drugs that cause NAFLD 5. Pregnant or trying to become pregnant 6. Inability to exercise on a bike or treadmill