We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.
In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed. We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group. Analyzing the diversity of the fungal and bacterial within colon mucosa between patients with different clinical classification, for example, the proportion of bacteria and fungi, the proportion of candida albicans, the proportion of yeasts, and so on.
Study Type
OBSERVATIONAL
Enrollment
50
We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
Qilu Hospital, Shandong University
Jinan, Shandong, China
RECRUITINGfungus detection rate
Fungi detection rate was defined as the percentage of patients in whose colonic mucosa at least one kind of fungus were identified.
Time frame: 6 months
yeasts detection rate
Yeasts detection rate was defined as the percentage of patients in whose colonic mucosa yeasts were identified.
Time frame: 6 months
candida albicans detection rate
Candida albicans detection rate was defined as the percentage of patients in whose colonic mucosa candida albicans were identified.
Time frame: 6 months
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