Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee

Inclusion Criteria: * Osteoarthritis of the knee according to American College of Rheumatology criteria: Knee pain with 3 of the following: * age \>50 years * stiffness less than 30 min * crepitus, * bony tenderness, * bony enlargement, * no palpable warmth * Moderate to severe pain, as defined by an average 7-day pain score of greater than 4.0 on an 11-point numerical rating scale for pain intensity (NRS-PI). * All concurrent medications taken for any reason stable for 14 days * Ability to follow protocol with reference to cognitive and situational factors (e.g. stable housing, ability to attend visits) * Ability to read and write English * Willing and able to give informed consent Exclusion Criteria: * Currently using other topical agents for treatment of pain or inflammation * Use of glucosamine, methysulfonylmethane or other regular anti-inflammatories within 2 weeks prior to completing baseline pain measure and during the trial * Presence of significant medical disorder that would compromise the participant's safety to take part in the trial (e.g. cancer, immunosuppressed) * Pregnant and breastfeeding women. * Type I or Type II diabetes and other endocrine disorders * Use of exercise or transcutaneous electrical nerve stimulation prior to and during the trial * A history or present disease (i.e. inflammatory, infectious joint disease) which may affect the outcome of the trial * Currently taking NHPs for joint health * Currently enrolled in other clinical trial involving a pharmaceutical treatment