Duration of Doxycycline Treatment in EM Patients

University Medical Centre Ljubljana300 enrolled

Overview

The purpose of this study is to compare the efficacy of 7-day versus 14-day doxycycline treatment in patients with erythema migrans.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

300

Conditions

Erythema Chronicum Migrans

Interventions

Doxycycline 100 MG Oral Tablet bid, 7 daysDRUG

Patients will receive doxycycline for 7 days.

Doxycycline 100 MG Oral Tablet bid, 14 daysDRUG

Patients will receive doxycycline for 14 days.

Controls without a history of lyme disease.DRUG

No intervention.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * solitary erythema migrans Exclusion Criteria: * pregnancy or lactation * immunocompromised * serious adverse event to doxycycline * taking antibiotic with antiborrelial activity within 10 days * multiple erythema migrans or extracutaneous manifestations of lyme borreliosis

Locations (1)

University Medical centzer Ljubljana

Ljubljana, Slovenia

Outcomes

Primary Outcomes

Treatment outcome in patients treated for erythema migrans with doxycycline for 7 or 14 days

Objective sequelae and post-treatment subjective new or increased symptoms (NOIS) in patients treated for erythema migrans with doxycycline for 7 or 14 days.

Time frame: At 12 months after enrollment.

Secondary Outcomes

Comparison of nonspecific symptoms in patients with erythema migrans and control subjects

Number of patients after treatment with doxycycline for 7 or 14 days for erythema migrans and number of control subjects (without a history o Lyme borreliosis) with nonspecific symptoms.

Time frame: At 12 months after enrollment.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.