To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li classification in a Population of adults suspected of infective endocarditis.
Study Type
OBSERVATIONAL
Enrollment
269
For each patient, one single high volume blood culture (3 aerobic and 3 anaerobic of 8 to 10 mL each, numbered), and then 2 samples of 16 to 20 mL (one aerobic bottle and one anaerobic for each sample).
Hôpital Nord Franche Comté
Belfort, France
Centre Hospitalier universitaire de Besançon
Besançon, France
Centre Hospitalier universitaire de Dijon
Dijon, France
Centre hospitalier Universitaire de Nancy
Nancy, France
Compared performance of a single high volume blood culture vs. multiple blood culture of usual volume for the diagnosis of infective endocarditis
Sensitivity/Specificity/Accuracy of positive bloodculture sets vs. final diagnosis assessed by the medical team (gold standard)
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
Diagnostic performance of the single high volume blood culture for the diagnosis of infective endocarditis
according to the level of suspicion of infective endocarditis, the type of microorganism involved, the underlying cardiopathy.
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
Measuring the nursing time required for both sampling methods.
Time for blood culture setting, processing and sending
Time frame: At T0, i.e. at the inclusion of the patient
Diagnosis of infective endocarditis: confirmed, possible or excluded
Applying the Classification of Duke-Li according to the modified diagnostic criteria of the European Society of Cardiology Recommendations 2015.
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
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Hopital BIchat Claude Bernard
Paris, France
Centre Hospitalier Universitaire de Reims
Reims, France
Centre Hospitalier Univesitaire de Rennes
Rennes, France
Hôpitaux Civils de Strasbourg
Strasbourg, France