The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation

Sohag University41 enrolled

Overview

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Sperm cryopreservation is considered the most valuable and used way to preserve male reproductive function. Unfortunately, osmotic effects of freezing and thawing during the cryopreservation process negatively affect sperm morphology and motility . Myoinositol is the most biologically important form of inositol in nature. In male reproductive system, myoinositol appears to regulate sperm motility, capacitation and acrosomal reaction. The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Myoinositol Cryopreservation Human Sperm

Interventions

MyoinositolBIOLOGICAL

Eligibility

Sex: MALEMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile men with normal or abnormal semen analysis Exclusion Criteria: * Azoospermic samples

Outcomes

Primary Outcomes

Cryo-survival rate

Post-thawing cryo-survival rates of both aliquots ( myo and control) are compared in both groups (A and B).

Time frame: 7 months

Data from ClinicalTrials.gov

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