CSD170201: A Study to Evaluate the Exposure to Tobacco Constituents From Two Moist Snuff Products

Inclusion Criteria: 1. Able to read, understand, and willing to sign an Informed Consent Form (ICF) written in English; 2. Generally healthy males and females, 21 years of age or older, at Screening-Enrollment Visit; 3. Self-reports currently using at least two cans of moist snuff per week; 4. Self-reports that moist snuff is the only tobacco- or nicotine-containing product used within 30 days of the Screening-Enrollment Visit; 5. Usual brand (UB) of moist snuff is one of the products specified in the protocol; 6. Used their UB product for ≥ 3 months; 7. Subject is not delaying a decision to quit using moist snuff to participate in the study; 8. Agrees to exclusively use the study products and not use any other tobacco- or nicotine-containing products during the course of the study; 9. Able to safely perform the required study procedures, as determined by the Investigator. Exclusion Criteria: 1. Self-reported history of heart disease, kidney disease, diabetes, liver disease, uncontrolled hypertension, or uncontrolled hypercholesterolemia; 2. At risk for heart disease, i.e., obesity (body mass index \[BMI\] \> 43 kg/m2), as determined by the Investigator; 3. Females ≥ 35 years of age currently using systemic, estrogen-containing contraception, or hormone replacement therapy; 4. Use of any medication or substance that aids in smoking cessation, including but not limited to any nicotine replacement therapy (NRT) (e.g., nicotine gum, lozenge, patch), varenicline (Chantix®), bupropion (Wellbutrin®, Zyban®), or lobelia extract within 30 days prior to the Screening-Enrollment Visit; 5. Females who are pregnant or breastfeeding, or plan to become pregnant during the course of the study; 6. Participation in another clinical study within 30 days prior to the Screening-Enrollment Visit. (The 30-day window for each subject will be derived from the date of the last study event in the previous study to the Screening-Enrollment Visit of the current study); 7. Determined by the Investigator to be ineligible for the study.