Efficacy of AposTherapy® in Knee OA

Inclusion Criteria: * Patients suffering from symptomatic unilateral or bilateral knee OA at the medial compartment for at least six months; * Fulfilling the ACR clinical criteria; * Having radiographically assessed OA of the knee with a Kellgren-Lawrence grade more than or equal to grade 2; and, * Having VAS-Pain ≥ 3, on a scale between 0-10. * Patients who have a shoe size between US 4 and US 12 Exclusion Criteria: * Patients suffering from acute septic arthritis. * Patients who received a corticosteroid injection within 3 months of the study. * Patients who received hyaluronic acid (HA) injections within 6 months of the study * Patients suffering from avascular necrosis of the knee. * Patients with a history of knee buckling or recent knee injury. * Patients who have had a joint replacement or other major surgery to the knee, hip or ankle (ipsilateral or contralateral side). * Patients suffering from neuropathic arthropathy. * Patients with an increased tendency to fall. * Patients exhibiting a lack of physical or mental ability to perform or comply with the study procedure. * Patients with a history of pathological osteoporotic fracture. * Patients suffering from symptomatic degenerative arthritis in lower limb joints other than the knees. * Patients with referred pain in the knees from primary back or hip joint pain. * Patients with neurological deficits to the lower extremity (ex. foot drop) * Patients whose shoe size is less than US 4 and greater than US 12 * Patients who have had arthroscopy within 6 months of the study * Patients with inflammatory arthropathy