The purpose of this study is to investigate the reference ranges and rates of gestational weight gain among Chinese pregnant women, and to analyze the correlation between gestational weight gain and adverse outcomes.
Study Type
OBSERVATIONAL
Enrollment
10,422
Preeclampsia
Maternal systolic pressure ≥140 mmHg and/or diastolic pressure ≥90 mmHg during gestation. Urine protein ≥5.0 g within 24h, urine volume \<400 mL. HELLP syndrome or pulmonary edema present.
Time frame: After 20th gestational weeks till delivery, about 5 months
Eclampsia
Tonic-clonic seizures (convulsions) in preeclampsia patients, including convulsions and coma, not due to pre-existing or organic brain disorders.
Time frame: After 20th gestational weeks till delivery, about 5 months
ICP
Intrahepatic cholestasis of pregnancy.
Time frame: After 14th gestational weeks till delivery, about 6 months
Placenta previa
Placenta partially or entirely covered the lower uterine segment diagnosed using antenatal ultrasound.
Time frame: During pregnancy till delivery
Gestational diabetes
By oral glucose tolerance test between 24th and 28th gestational weeks (fasting glucose ≥5.1 mmol/L, 1-h glucose ≥10.0 mmol/L, 2-h glucose ≥8.5 mmol/L; one abnormal result sufficient).
Time frame: After 24th gestational weeks, about 4 months
Ruptured uterus
Rupture of maternal uterus confirmed by laparotomy.
Time frame: During delivery
Placental abruption
Abruption of a normally positioned placenta before delivery, diagnosed by clinical symptoms, ultrasound, fetal heart monitoring, or laboratory tests.
Time frame: After 20th gestational weeks till delivery, about 5 months
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Postpartum hemorrhage
Postpartum bleeding volume ≥500 mL.
Time frame: Within 24h after delivery
Hepatic diseases
Hepatitis-B/C/E virus infection, acute fatty liver disease, or severe hepatitis.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Hematological diseases
Iron-deficiency anemia, thalassemia, hemophilia, idiopathic thrombocytopenic purpura, aplastic anemia, or disseminated intravascular coagulation.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Gynecological diseases
Uterine fibroids, ovarian cyst, cervical carcinoma, pelvic inflammation, or ovarian carcinoma.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Respiratory diseases
Pneumonia, bronchitis, asthma or pulmonary tuberculosis.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Thyroid disease
Hyperthyroidism or hypothyroidism.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
ICU admission
Admission to intensive care unit.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Maternal death
Maternal death.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Macrosomia
Birth weight \>4000 g.
Time frame: within 1 month after delivery
Infant of low-birth weight
Birth weight \<2500 g.
Time frame: within 1 month after delivery
Neonatal ICU admission
Admission to neonatal intensive care unit.
Time frame: Within 1 month after delivery
Neonatal death
Neonatal death.
Time frame: Within 1 month after delivery
Large for gestational age
Neonatal weight, length, or head circumference above the 90th percentile for that gestational age.
Time frame: Within 1 month after delivery
Small for gestational age
Neonatal weight, length, or head circumference below the 10th percentile for that gestational age.
Time frame: Within 1 month after delivery
Neonatal defect
Neonatal defect.
Time frame: Within 1 month after delivery
Maternal adverse outcomes
There occurred one or more of preeclampsia, eclampsia, ICP, placenta previa, gestational diabetes, ruptured uterus, placental abruption, postpartum hemorrhage, hepatic diseases, hematological diseases, gynecological diseases, respiratory diseases, thyroid disease, ICU admission, or maternal death.
Time frame: During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year
Neonatal adverse outcomes
There occurred one or more of macrosomia, low-birth weight, neonatal ICU admission, neonatal death, large for gestational age, small for gestational age, or neonatal defect.
Time frame: Within 1 month after delivery