The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.
Study Type
OBSERVATIONAL
Enrollment
500
Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest
Samsung Changwon Hospital
Changwon, South Korea
RECRUITINGChonnam National University
Gwangju, South Korea
RECRUITINGSeoul St. Mary's hospital
Seoul, South Korea
RECRUITINGComparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2
Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 uV.
Time frame: at day 180
Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5
Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 uV.
Time frame: at day 180
Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5
Unfavorable aEEG patterns include flat trace (FT), burst-suppression (BS) and status epilepticus (SE). FT is defined as isoelectric activity. BS is defined as the virtual absence of activity (\<2uV) between bursts of high voltage (\>25 uV). SE was defined as repetitive epileptiform discharges with amplitudes \>50 uV and a median frequency 1 Hz for \>30 min.
Time frame: at day 180
Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5
Time frame: at day 180
Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5
Time frame: at day 180
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KEPCO Medical Center
Seoul, South Korea
RECRUITINGComparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5
Time frame: at day 180