Bioavailability, Safety, and Tolerability of BIS-001 ER

Inclusion Criteria: 1. Speak English with sufficient proficiency to read and comprehend the Informed Consent document, and to communicate with study staff. 2. Be able to consent to participate by signing the Informed Consent document after a full explanation of the nature and purpose of this study. 3. Have signed the Informed Consent before any study-specific procedures are performed 4. Be males or females between 18 - 45 years of age. 5. Have a negative urinary pregnancy test upon admission to the site on Day 1 6. Be in good general health in the judgment of the Principal Investigator based upon medical history, physical examination, standard 12-lead electrocardiogram (ECG), and clinical laboratory evaluations obtained within the two weeks prior to enrollment. 7. Be able to comply with all study-specified procedures. 8. Weight between 40 and 100 kg Exclusion Criteria: 1. Has taken Huperzine A. 2. Is planning to become pregnant or impregnate spouse, not using an acceptable method of birth control (defined as use of double-barrier birth control methods, use of oral contraceptives, or surgical sterilization), pregnant or nursing 3. Has a pre-existing medical condition (including an existing progressive or degenerative neurological disorder) or takes medications that, in the Principal Investigator's opinion, could interfere with the subject's suitability for participation in the study. 4. Has a history or evidence of significant psychiatric disturbance or illness, including alcohol or drug abuse within the past 2 years, or symptoms of psychosis (hallucinations, delusions) in the last 5 years. 5. Has had any clinical laboratory abnormalities within the past two months, prior to screening, considered of clinical significance by the Principal Investigator 6. Is on concomitant therapy with non-anti-epileptic drugs (AEDs) that are cholinergic. 7. Has participated in any clinical investigational drug or device study within four weeks prior to study entry.