Bronchial basal cells are proved to be able to regenerate lung structures to repair the injured lung. In COPD patients, bronchus structures are injured and cannot be repaired, which may result in the failure of pulmonary function rescue clinically.In our research, autologous bronchial basal cells will be transplanted into lung of patients suffered with COPD to treat the disease. Specifically, autologous bronchial basal cells will be dissected from brushed-off samples by bronchofiberscope. Then, they will be expanded in vitro and transplanted into lung to regenerate new alveoli and bronchus structures and re-establish pulmonary system.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Patients will receive of clinical grade bronchial basal cells (BBCs) with a dosage of 10\^6 (1 million) cells/Kg/person via fiberoptic bronchoscopy after fully lavage of the localized lesions.
the First Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China
RECRUITINGForced expiratory volume in one second (FEV1)
An indicator for pulmonary function test to assess airway obstruction
Time frame: 1-6 months
Forced vital capacity (FVC)
An indicator for pulmonary function test to indicate the maximum amount of air a person can expel from the lungs after a maximum inhalation
Time frame: 1-6 months
Diffusion capacity of CO (DLCO)
An indicator for pulmonary function test to show the extent to which oxygen passes from the air sacs of the lungs into the blood
Time frame: 1-6 months
The ratio of forced expiratory volume in the first one second to the forced vital capacity (FEV1/FVC)
An indicator in pulmonary function test to represent the proportion of a person's vital capacity that they are able to expire in the first second of forced expiration to the full vital capacity
Time frame: 1-6 months
Maximum mid-expiratory flow (MMF)
An indicator in pulmonary function test to stand for maximal (mid-)expiratory flow and is the peak of expiratory flow as taken from the flow-volume curve and measured in liters per second
Time frame: 1-6 months
Maximum voluntary ventilation (MVV)
An indicator in pulmonary function test to measure the maximum amount of air that can be inhaled and exhaled within one minute
Time frame: 1-6 months
6-minute-walk test (6MWT)
An indicator to evaluate the exercise function of patients with moderate or severe pulmonary heart diseases
Time frame: 1-6 months
Modified medical research council (MMRC) chronic dyspnea scale
An indicator to evaluate the level of dyspnea
Time frame: 1-6 months
St. George's respiratory questionnaire (SGRQ) scale
A questionnaire to assess life quality affected by the respiratory problems
Time frame: 1-6 months
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