Application Value of CTCs Detection for Advanced Gastric Cancer Patients

Inclusion Criteria: Subjects eligible for enrollment must meet all of the following criteria: 1. Provide signed informed consent. The subject is capable of understanding and complying with parameters as outlined in the protocol and able to sign informed consent, approved by the Independent Ethic Committee (IEC)/Institutional Review Board (IRB) prior to the initiation of any study-specific procedures 2. Men or women aged \>= 18 years and \<=75 years. 3. Eastern Cooperative Oncology Group Performance Status (ECOG) \<= 2. 4. Histologically confirmed adenocarcinoma of the stomach, gastroesophageal junction. 5. Metastatic disease or locally advanced disease not amenable to curative surgery. 6. Radiographically assessable, non-measurable disease or measurable disease as per RECIST criteria. 7. Life expectancy of at least 12 weeks with tumor and at least 5 years without tumor from the time of enrollment. 8. No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix. 9. No prior chemotherapy for advanced disease. - Exclusion Criteria: Subjects meeting any of the following criteria must not be enrolled in the study: 1. Gastric carcinoid, sarcomas, or squamous cell cancer. 2. Pregnant or lactating females. 3. Significant neurological or psychiatric disorders (psychotic disorders, dementia or seizures) that would prohibit the understanding and giving of informed consent. 4. Active Hepatitis B or C or history of an HIV infection. 5. Active uncontrolled infection. -