Safety and Efficacy of Immune Therapy for Condyloma

Shenzhen Second People's Hospital80 enrolled

Overview

Cytokine-induced killer (CIK) cells will be co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to Condylomata Acuminata patients using interferon, whose recurrence rate and total cost will be compared to Condylomata Acuminata patients only use interferon.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Condylomata Acuminata

Interventions

DC-CIK immunotherapyBIOLOGICAL

Cytokine-induced killer (CIK) cells are co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to condylomata acuminata patients

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria:All patients have typical clinical characters of condyloma, positive for HPV-DNA test; All patients have been treated for cryotherapy or laser plus interferon for over half a year without completely recovery. All patients or their family will sign informed consent and approved by Ethics Committee of Shenzhen Second People's Hospital - Exclusion Criteria:pregnant, blood disease, contraindication for immune therapy, allergic to interferon \-

Locations (1)

Shenzhen Second Hospital

Shenzhen, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

Condylomata Acuminata recurrence rate

Condylomata Acuminata recurrence rate in 6 months after treatment

Time frame: 6 months

Secondary Outcomes

skin tissue HPV gene

use PCR to testify skin tissue HPV gene

Time frame: 6 months

side effect

evaluate and record side effect of each group

Time frame: 6 months

Data from ClinicalTrials.gov

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