Safety and Pharmacokinetics/Pharmacodynamics of SHR3824 in Type 2 Diabetes Patients With Renal Insufficient

Inclusion Criteria: * with a body mass index(BMI) between 19 and 33 Kg/m2; * The estimated glomerular filtration rate (eGFR)of subjects in groups must meet the corresponding standards:mild renal insufficiency:60 to 89 ml/min/1.73m2;Moderate renal insufficiency: 30 to 59 ml/min/1.73m2. * Had signed the informed consent himself or herself voluntarily. Exclusion Criteria: * Urinary tract infections, or vulvovaginal mycotic infections * Suspected or diagnosed as kidney cancer or other malignancies in patients * Autoimmune kidney disease, history of renal transplantation, dialysis patients being treated * History of or current clinically significant medical illness as determined by the Investigator * History of clinically significant allergies, especially known hypersensitivity or intolerance to lactose * Known allergy to SHR3824,SGLT2 inhibitor analogs, or any other structural analogs * Alcohol, tobacco, drug abusers;alcohol abuse is defined as a day for regular alcohol consumption more than the following standards: beer 570 ml, light beer 750 ml, red wine 200 ml, white wine 60 ml, which including about 20g alcohol;Tobacco is defined as five or more per day. * Pregnancy or lactation women, or a fertility male or female is not willing to contraception during test. * Researchers considered that there was any situation that may cause the participants can't finish this study or bring any obvious risk to subjects.