Improving Keloids Using Targeted Ultraviolet-B Irradiation

Johns Hopkins University2 enrolled

Overview

Treatment of keloids with targeted Ultraviolet-Beta (UVB) radiation will improve the clinical appearance and induration of lesions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Keloid

Interventions

NB-UVBDEVICE

NB-UVB has an emission spectrum in the ultraviolet B range of 290-320 nm. The system consists of a light source, a spot handpiece, and a light guide that connects the handpiece to the light source. The light source has a Start/Stop switch for light beam activation. Activation can also be controlled remotely with a foot switch. The light source has a timer and an output level control to adjust the intensity of the ultraviolet light. This will be calibrated using a manufacturer-provided UV meter prior to every treatment to ensure accurate doses of ultraviolet light.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants must be 18 years old or over * Participants must have a diagnosis of keloid * No treatment with topical or intralesional steroids for 1 month prior to study Exclusion Criteria: * Patients who are unable to provide informed consent * A history of photosensitivity, lupus erythematosus, porphyria or current use of a known photosensitizing drug * Unwillingness to stop with topical or intralesional steroids for 1 month prior to study * A history of malignant melanoma * A history of radiation therapy to area of interest * Subjects who self-report that they are pregnant or nursing

Outcomes

Primary Outcomes

Clinical Appearance As Assessed by the Patient and Observer Scar Assessment (POSAS) Scale

Investigators will evaluate the pre- and post-study clinical photographs of all participants. The grading investigator will grade the degree of improvement using the POSAS scale to measure the clinical appearance of the keloids

Time frame: 16 weeks

Data from ClinicalTrials.gov

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