The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.
Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.
Study Type
OBSERVATIONAL
Enrollment
39
Immunohistochemistry procedure on the formalin-fixed, paraffin-embedded tissue.
CIUSSS de l'Estrie - CHUS
Sherbrooke, Quebec, Canada
Expression pattern of the studied protein convertase
Horseradish peroxidase staining with specific antibodies.
Time frame: Trough study completion, an average of 1 year after the patients have been operated.
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