Intraosseous PRP for Knee Osteoarthritis: Pilot Study

Inclusion Criteria: * Patients of both sexes aged 40 to 77 years. * Predominant internal tibiofemoral knee osteoarthritis. * Joint pain above 2.5 VAS points. * Radiographic severity degrees 3 and 4 according to Ahlbäck scale. * Values of body mass index between 20 and 33. * Possibility for observation during the follow-up period. Exclusion Criteria: * Bilateral knee osteoarthritis which requires infiltration in both knees. * Values of body mass index \> 33. * Polyarticular disease diagnosed. * Severe mechanical deformity (diaphyseal varus of 4∘ and valgus of 16∘). * Arthroscopy in the last year prior to treatment. * Intra-articular infiltration of hyaluronic acid in the past 6 months. * Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis). * Poorly controlled diabetes mellitus (glycosylated hemoglobin above 9%). * Blood disorders (thrombopathy, thrombocytopenia, and anemia with Hb \< 9). * Undergoing immunosuppressive therapy and/or warfarin. * Treatment with corticosteroids during the 6 months prior to inclusion in the study.