A Study of Tongue Conservation Surgery for Oral Tongue Cancer

Inclusion Criteria: * Patients with histological proof of squamous cell carcinoma of oral tongue * b. cT2-4, N0-2,M0, by clinical or radiographic examinations * Either mandibulotomy, mandibulectomy or flap reconstruction is required by standard surgical planning * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 * Between 20 and 70 years of age * Adequate hematopoietic function as defined below: Hemoglobin \>= 10g/dl Absolute neutrophil count (ANC) \>= 1,500/µL Platelets \>= 100,000/µL * Adequate organ function as defined below: Total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine \<= 1.5 x upper limit of normal Creatinine clearance \> 50 ml/min * Signed study-specific consent form prior to study entry Exclusion Criteria: * Patients received gross oral tongue tumor resection before evaluation * Primary subsites other than oral tongue * Histologic diagnosis other than squamous cell carcinoma * Patient with synchronous primary cancers (within 6 months) * Clinical or radiographic findings as below: T1 tumors Gross invasion to mandible, tonsil or \>1/3 base of tongue N3 disease or distant metastasis (M1) * Prior head and neck chemotherapy or radiotherapy * Prior esophageal cancer history * Active cardiac disease defined as: unstable angina, uncontrolled arrhythmia, myocardial infarction within 6 months. * Severe chronic obstructive pulmonary disease (COPD) requiring ≥ 3 hospitalizations over the past year * Mental status not fit for clinical trial. * Pregnant or breast feeding women, or women of child-bearing potential unless using a reliable and appropriate contraceptive method.