The Effect of Mannitol on the Serum Potassium During Craniotomy

N/ACompletedNCT03161977

The Affiliated Hospital of Xuzhou Medical University30 enrolled

Overview

This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.

Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mannitol Adverse Reaction Hyperkalemia

Interventions

MannitolOTHER

Mannitol was intravenous infused within 15-20 mins when drilling skull

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 to 70 * American Society of Anesthesiologists physical status I to II * liver and kidney function is normal * preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L Exclusion Criteria: * history or presence of congestive heart failure (New York Heart Association class III to IV) * history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion) * intraoperative blood transfusion

Locations (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Outcomes

Primary Outcomes

the concentration of serum potassium

measured by arterial blood gas analysis

Time frame: two hours within infusioning mannitol

Data from ClinicalTrials.gov

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