Assessment of Mandibular Osseous Changes in Patients With End Stage Renal Failure

N/AUnknownNCT03162029

Cairo University26 enrolled

Overview

This study will be observational study. The goal of this study is to evaluate the quality of mandible and to assess the correlation between the jaw bone quality in a sample of Egyptian patients with chronic renal failure and duration of dialysis using CBCT. Twenty-six subjects will be included in this study. These will comprise (13) CKD patients "the study group" and (13) healthy patients "the control group" recommended for CBCT imaging for implant placement. The control group will be selected from the Prosthodontic department and Oral Medicine department of Faculty of Oral and Dental Medicine, Cairo University, the study group will be selected from Nephrology and the artificial kidney unit El Kasr -Al Ain Hospital, Cairo University.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diagnosis

Interventions

CBCT imagingOTHER

CBCT imaging of participants, then take measurement by radiomorphometric indices

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * End stage renal failure (in study group) * Undergone hemo-dialysis, three times/week (in study group) * Duration of dialysis (≥1 year) (in study group) * PTH (140-630) * Age group (18-40 years) * Mandible * Free from any other systemic disease affecting the bone quality * Egyptian population Exclusion Criteria: * Early stage of renal disease * Patients with diabetes, hyperthyroidism, postmenopausal osteoporosis * Maxilla * Other language * Completely Edentulous patients.

Outcomes

Primary Outcomes

Mandibular cortical index(MCI)

Mandibular cortical index (MCI) is a qualitative index that determines the porosity degree of the lower cortical border of the mandible distal to the mental foramen.The lower border of the mandible can be classified into a three point scale according to MCI, C1: the cortex is sharp on both sides; C2: the cortex had semilunar defects(lacunar resorption) and c3: cortex is clearly porous

Time frame: Five months

Secondary Outcomes

Mental index(MI)

The quantitative index that used for cortical width measurement at the mental foramen region

Time frame: Five months

Panoramic mandibular index(PMI)

Measure the mandibular cortical thickness in relation to the distance between the mental foramen and the inferior border of mandible

Time frame: Fivemonths

Anti-gonial index(AI)

A quantitative index measure the cortical width in the region that is anterior to the gonion

Time frame: Five months

Central Contacts

Eman M Mohamed, MSc

CONTACT

01116226642 eman.mamdouh.87@gmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.