A 12-week randomized controlled trail was conducted in 72 Chinese breast cancer survivors who had received aromatase inhibitors treatment for more than 6 months. All participants were assigned to either 12 weeks of Baduanjin classes which involved to two 90-minute sessions per week or a wait-list control. Participants completed fitness assessments, measurements of lipopolysaccharide-stimulated production of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β(IL-1β) ,C-reactive protein (CRP) ,BMI,BMD and questionnaires to measure QoL, fatigue, sleep quality, Aromatase Inhibitor-Induced Arthralgia, symptoms of climacteric syndrome were completed at baseline and 3 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
86
Guangdong General Hospital
Guangzhou, Guangdong, China
Change from Baseline Quality of Life (QoL) at 3 months
European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 version 3 (EORTC QLQ-C30)
Time frame: at baseline and 3 months
Change from Baseline IL-6 at 3 months
proinflammatory cytokines interleukin-6
Time frame: at baseline and 3 months
Change from Baseline Fatigue at 3 months
Piper fatigue questionnaire
Time frame: at baseline and 3 months
Change from Baseline sleep quality at 3 months
Pittsburgh sleep quality index, PSQI
Time frame: at baseline and 3 months
Change from Baseline Aromatase Inhibitor-Induced Arthralgia at 3 months
Brief Pain Inventory-Short Form
Time frame: at baseline and 3 months
Change from Baseline Symptoms of climacteric syndrome at 3 months
Kupperman Index
Time frame: at baseline and 3 months
Change from Baseline BMD at 3 months
Bone mineral density
Time frame: at baseline and 3 months
Change from Baseline BMI at 3 months
Body Mass Index
Time frame: at baseline and 3 months
Change from Baseline Aerobic Fitness Assessment at 3 months
Six-min walk test (6MWT)
Time frame: at baseline and 3 months
Change from Baseline Muscle strength test at 3 months
Upper strength: hand grip (measured by a dynamometer; the average of 3 readings) lower limb strength:sit-to-stand (measured as number of reps in a 30-s period)
Time frame: at baseline and 3 months
Change from Baseline Flexibility test at 3 months
Test of scratching his back and Sit in the chair and reach
Time frame: at baseline and 3 months
Change from Baseline Balance test at 3 months
stand on one foot
Time frame: at baseline and 3 months
Change from Baseline TNF-α at 3 months
tumor necrosis factor alpha
Time frame: at baseline and 3 months
Change from Baseline IL-1β at 3 months
interleukin-1β
Time frame: at baseline and 3 months
Change from Baseline CRP at 3 months
C-reactive protein
Time frame: at baseline and 3 months
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