The Value of Progesterone for the Timing of the Embryo Transfer in IVF/ICSI: a Prospective Randomised Trial

University Hospital, Ghent24 enrolled

Overview

At the start of the controlled ovarian stimulation as a part of the IVF/ICSI treatment patients are informed about this trial. In case they gave informed consent and they have a progesterone level between 1 and 1.5 ng/ml at the day of the hCG injection, they will be randomised. One group of patients will have a fresh embryo transfer, in the second group all embryos will be cryopreserved and transfered in a subsequent (natural or artificial) cycle. The aim of this study is to compare clinical pregnancy rate between the two groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Clinical Pregnancy Rate

Interventions

Freeze allPROCEDURE

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * IVF/ICSI treatment * progesterone \> 1 ng/ml and ≤ 1.5 ng/ml Exclusion Criteria: * \> 40 years * AMH ≤ 1 ng/ml * Conditions influencing pregnancy rate (e.g. hydrosalphinx, uterus malformation, hyperprolactinemia and other endocrine conditions; with the exception of controlled thyroid function disease) * no available progesterone value on the day of hCG-injection

Locations (1)

Ghent University Hospital - Department of Reproductive Medicine

Ghent, Belgium

Outcomes

Primary Outcomes

Clinical pregnancy rate

Time frame: 7 gestational weeks

Secondary Outcomes

Ongoing pregnancy rate

Time frame: 25 gestational weeks

Live birth rate

Time frame: Delivery

Data from ClinicalTrials.gov

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