The objective of this research is to evaluate the correlation between DECT and US explorations performed in a routine clinical setting for the measurement of change in tophus size in gout patients after 24 months of treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
The tophus volume will be assess using ultrasonography.
The tophus volume will be assess using dual-energy computed tomography (DECT).
Hospital Group of the Catholic Institute
Lomme, France
Bichat Hospital
Paris, France
Lariboisière Hospital
Paris, France
Correlation between US and DECT measurement of change in tophus volume
Spearman rank correlation between the change in tophus volume after 24 months of treatment measured by ultrasonography or by DECT.
Time frame: after 24 months of treatment
Correlation between US and DECT measurement of change in tophus volume
Spearman rank correlation between the change in tophus volume after 6, 12 and 24 months of treatment measured by ultrasonography or by DECT.
Time frame: after 6 months, 12 months and 24 months of treatment
Change of DECT urate score
Change from baseline after 6, 12 and 24 months of treatment in DECT urate score
Time frame: after 6 months, 12 months and 24 months of treatment
Link between the change of DECT urate score and the persistence of the double contour sign
During ultrasonography, a double contour of the articulation can be visible. This outcome will compare the change in the DECT urate score between the patients for who the double contour stay visible and those for who it disapear. This outcome register if this double contour stay visible.
Time frame: after 6 months, 12 months and 24 months of treatment
Correlation between the change of DECT urate score and the change in serum uric acid levels
The Spearman correlation between the change from baseline of the DECT urate score and the serum uric acid levels will be computed for each time point.
Time frame: after 6 months, 12 months and 24 months of treatment
Correlation between the change of DECT urate score and the number of gout attacks
The Spearman correlation between the change from baseline of the DECT urate score and the number of gout attack will be computed.
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Time frame: after 6 months, 12 months and 24 months of treatment