To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chronic Liver Failure (ACLF).

Inclusion Criteria: \- All consecutive patients in age group of 18-70 years with acute on chronic liver failure as defined by APASL criteria shall be included in the study.Only those patients who wish to be enrolled in the trial shall be included in the study. Exclusion Criteria: 1. Steroid eligible patients with severe alcoholic hepatitis 2. Cirrhosis of liver with previous history of decompensation 3. Patients with severe cardiopulmonary disease 4. Pregnancy 5. Human Immmunodeficiency Virus infection 6. Hepatocellular carcinoma or extrahepatic malignancy 7. Chronic renal insufficiency on treatment with haemodialysis 8. Uncontrolled bleed or patients in disseminated intravascular coagulopathy 9. Patient with expected survival of less than 48 hours 10. Patients with moderate-severe acute respiratory distress syndrome 11. Hemodynamic instability with noradrenaline requirement of more than \>0.5ug/kg/min or requirement of dual vasopressors 12. Patients with leukemoid reaction or total leucocyte count \> 40,000/mm3 13. Patients diagnosed with Hemophagocytic Lymphohistiocytosis 14. Patients with known hypersensitivity to Granulocyte colony stimulating factor