This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint osteoarthritis.
Osteoarthritis (OA) is a chronic progressive disease, characterized by degradation of joint cartilage, synovial inflammation and joint dysfunction. This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint OA. Samples of synovial fluid (SF) from the patients with the OA (ICD-10 codes: M15, M16 and M17) will be assessed for T-cell subsets, msast cells, fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) by flow cytometry. Subpopulations of blood T-cells involved in the inflammation will also be assayed. Standard clinical investigation will be performed and the results will be used to estimate the laboratory criteria or degrees of activity of medium and large joint OA.
Study Type
OBSERVATIONAL
Enrollment
121
Andrei Hancharou
Minsk, Belarus
The sensitivity of the proposed laboratory-based method in the diagnostics of the activity of osteoarthritis
The sensitivity of the proposed laboratory-based method in the diagnostics of the activity of medium and large joint osteoarthritis
Time frame: 2 month
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