Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Assiut University60 enrolled

Overview

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Endometrial Adenocarcinoma

Interventions

KetamineDRUG

patients receive local anesthetic wound infiltration with 1 mg /kg ketamine

dexmedetomidineDRUG

patients receive local anesthetic wound infiltration with 1µg/kg dexmedetomidine

bupivacaineDRUG

patients receive local anesthetic wound infiltration with bupivacaine 0.5 % diluted in 20 ml saline

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-II patients * age range (18-60) years, * weight (50- 90) kg Exclusion Criteria: * allergy to study drugs * significant cardiac disease * respiratory disease * renal disease * hepatic disease

Locations (1)

South Egypt Cancer instIitute

Asyut, Egypt

Outcomes

Primary Outcomes

severity of pain at rest and on coughing

severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain)

Time frame: 24 hours

Secondary Outcomes

sedation

sedation by using sedation score

Time frame: 24 hours

Data from ClinicalTrials.gov

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