Efficacy and Safety of Jinshuibao Capsule on Diabetic Kidney Disease

Inclusion Criteria: 1. Subjects with written informed consent. 2. Type 2 diabetes according to 1999 WHO criteria. 3. Age: 30-75 years. 4. HbA1c \< 11%. 5. Stage III diabetic kidney disease: 5.1 microalbuminuria: 30 mg / g \< urinary albumin creatinine ratio (ACR) \< 300 mg / g, positive for at least two in three times. 5.2 renal function: eGFR ≧ 30 ml / min / 1.73 ㎡. 6. Stable use of a standard dose of angiotensin II receptor blocker ≧ 3 months. 7. Childbearing-age women with contraceptive measures. Exclusion Criteria： 1. Type 1 Diabetes Mellitus. 2. Non-diabetic urinary system diseases (Urinary tract obstruction, bladder emptying disorders, severe benign prostatic hyperplasia, renal vascular disease, post-renal transplantation, active urinary tract infection,etc.) 3. Other serious diseases \[severe hypertension ((defined as SBP \> 200 mmHg and/or DBP \> 110 mmHg, or requiring ≧3 anti-hypertensive drugs simultaneously), cardiovascular and cerebrovascular events within 6 months, autoimmune diseases implicating the urinary system, chronic or acute pancreatitis, malignancy, hepatic abnormalities (transaminase ≧ 3.0 x UNL), severe gastrointestinal diseases, other endocrine diseases affecting the urinary system, etc.\] 4. Allergic to Cordyceps sinensis, use of ACEIs, any use of Cordyceps sinensis preparations, systemic glucocorticoid treatment ≧ 7 days within a month, use of nephrotoxic drugs within 3 months, alcohol or psychotropic drug dependence, etc. 5. Presence of acute metabolic disorders (DKA,HHS); history of surgery, severe trauma and other stress conditions. 6. Female patients who are pregnant or breastfeeding. Any medical condition that, in the opinion of the investigator, will interfere with participation in the trial.