GDFT Based on PPV Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: RCT

Mahidol University60 enrolled

Overview

The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing complex spine surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Spine Disease

Interventions

goal directed fluid therapyPROCEDURE

pulse pressure variation will be used to as a goal to guide fluid administration in this group

ControlledOTHER

standard fluid treatment by an anesthesiologist

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA 1-3 * elective surgery * thoracic/lumbar spine surgery \>= 3 levels and duration \>= 3 hours Exclusion Criteria: * Cr \>2 mg/dl or eGFR \< 60 ml/min * coronary artery disease, congestive heart failure or cardiac arrhythmia * BMI \>30 kg/m2 * hemodynamic unstable, preoperatively * uncontrolled hypertension * respiratory system compliance \< 30 ml/cmH2O

Locations (1)

Faculty of Medicine Siriraj Hospital

Bangkok Noi, Bangkok, Thailand

Outcomes

Primary Outcomes

episode of intraoperative hypotension

Blood pressure will be record continuously using arterial catheter in both group. Number of participants and episode of hypotension (defined as SBP \< 90 mmHg or MAP \< 60 mmHg or decrease of SPB \>= 25% from baseline for 5 minutes or need vasopressor) therapy

Time frame: intraoperative

Secondary Outcomes

unit of blood transfusion

all unit of blood transfusion will be record intraoperative and postoperative

Time frame: intraoperative and up to 24 hours postoperatively

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.