Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.

University of Zurich165 enrolled

Overview

The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participated in the study in 2012 to undergo follow-up examinations in 2017, in order to allow comparisons of current results with baseline data from 2012.

Study Type

OBSERVATIONAL

Enrollment

165

Conditions

High Altitude Pulmonary Hypertension Sleep Apnea

Eligibility

Sex: ALLMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence. * healthy subjects (high altitude controls) * Both genders * Age \>16 y * Kyrgyz ethnicity * born, raised and currently living at \>2500 m * healthy subjects currently living at \<1000 m (low altitude controls) Exclusion Criteria: * Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography * Excessive erythrocytosis * Other coexistent disorders that may interfere with the cardio-respiratory system and sleep * Regular use of medication that affects control of breathing * Heavy smoking

Locations (1)

National Center for Cardiology and Internal Medicine

Bishkek, Kyrgyzstan

Outcomes

Primary Outcomes

Changes in pulmonary artery pressure

Difference in the change in mean pulmonary artery pressure (mPAP measured by echocardiography) 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Secondary Outcomes

Changes in nocturnal arterial oxygen saturation

Difference in the change in the nocturnal arterial oxygen saturation 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Survival

Cumulative incidence of death and relocation to lower altitudes between 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Progression of oxygen desaturation index

Difference in the change in the oxygen desaturation index 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Progression of quality of life

Difference in the change in the mental and physical component score of the SF-36 questionnaire 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Progression of cognitive performance

Difference in the change in the mean reaction time 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander

Time frame: Year 2012 to 2017

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.