Right Ventricular Function During Exercise in Highlanders/Lowlanders

University of Zurich173 enrolled

Overview

The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross-sectional case-control study.

Study Type

OBSERVATIONAL

Enrollment

173

Conditions

High Altitude Pulmonary Hypertension

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence. * healthy subjects (high altitude controls) * Both genders * Age \>16 y * Kyrgyz ethnicity * born, raised and currently living at \>2500 m * healthy subjects currently living at \<1000 m (low altitude controls) Exclusion Criteria: * Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography * Excessive erythrocytosis * Other coexistent disorders that may interfere with the cardio-respiratory system and sleep * Regular use of medication that affects control of breathing * Heavy smoking

Locations (1)

National Center for Cardiology and Internal Medicine

Bishkek, Kyrgyzstan

Outcomes

Primary Outcomes

pulmonary artery pressure (PAP) during exercise

Difference in change of tricuspid pressure gradient during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Time frame: Day 2

Secondary Outcomes

cardiac output (CO) during exercise

Difference in change of cardiac output during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Time frame: Day 2

PAP/CO slope during exercise

Difference in change of PAP/CO slope during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Time frame: Day 2

Oxygen saturation

Difference in change of oxygen saturation during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Time frame: Day 2

Data from ClinicalTrials.gov

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