According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups. The different combinations of propofol and sevoflurane were used in the four groups: 1 day before surgery, after patients become wide-awake, and 3 days, 7 days, and 3 months after surgery, the patient's cognitive function was evaluated using a professional cognitive scale and other indicators. Finally, statistical analysis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
Propofol is the most common clinical anesthetics.
Sevoflurane is the most common clinical anesthetics.
Third Central Hospital of Tianjin
Tianjin, Tianjin Municipality, China
RECRUITINGEvidence of clinically cognitive function decline ：Apolipoprotein J（ApoJ）
Measurement by ELISA kit
Time frame: Change from Baseline Apolipoprotein J at 7 days
Evidence of clinically cognitive function decline ：Soluble CD14（sCD14）
Estimating by ELISA kit
Time frame: Change from Baseline Soluble CD14 at 7 days
Mini mental Examination(MMSE)
A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0\~30，≦27 were considered as cognitive function decline
Time frame: preoperative 24 hours ， 7 days post surgery
Montreal Cognitive Assessment（MoCA)
A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0\~30，≦27 were considered as cognitive function decline.
Time frame: preoperative 24 hours ，7 days post surgery
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