Osteoarthritis (OA) is one of the most common joint diseases that is considered a chronic degenerative disorder. There is no effective therapy available today. This prospective clinical trial is designed in an attempt to study the efficacy of mesenchymal stem cells with platelet rich plasma in knee osteoarthritis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Allogeneic UC-MSCs 1 x 10\~7 diluted on 5 mL of Platelet Rich Plasma
intra-articular injection of Hyaluronic Acid
Liaocheng city people's hospital
Liaocheng, Shandong, China
RECRUITINGChange From Baseline in visual analogue scale (VAS)
Visual analogue scale (VAS)
Time frame: Baseline, 1, 3, 6 and 12 weeks
Change From Baseline in western Ontario and McMaster Universities Osteoarthritis Index score
WOMAC
Time frame: Baseline, 1, 3, 6 and 12 weeks
Change From Baseline in knee society score (KSS)
knee society score (KSS)
Time frame: Baseline, 1, 3, 6 and 12 weeks
Change From Baseline in MOS item short from health survey(SF-36)
The MOS item short from health survey(SF-36)
Time frame: Baseline, 1, 3, 6 and 12 weeks
The number of cartilage defects, thickness of cartilage evaluated by X-ray and MRI
Time frame: Baseline, 1, 3, 6 and 12 weeks
The IL-1β, IL-6, PGE-2, TGF-β, TNF-α and IGF-1 of articular cavity fluid
The IL-1β, IL-6, PGE-2, TGF-β, TNF-α and IGF-1 of articular cavity fluid
Time frame: Baseline, 1, 3, 6 and 12 weeks
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