The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player. Activation of BAT results in enhanced energy expenditure and promotes weight loss. Here, the investigators will study the effects of bariatric surgery on BAT function by PET/CT studies and molecular analyses of adipose biopsies. The investigators will explore different pathways that may affect BAT activation in this patient population.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Patients will undergo bariatric surgery as routinely scheduled. The type of bariatric procedure will be suggested by the surgeon based on clinical considerations.
Medical University of Vienna
Vienna, Austria
Changes in BAT activity after bariatric surgery
The primary outcome of this study is to determine whether Omega Loop Gastric Bypass and Sleeve Gastrectomy result in increased BAT activity
Time frame: 4 years
Bariatric surgery-induced changes in gut microbiota, bile acid composition and other circulating factors
Any pre-versus postsurgical changes of the gut microbiota or bile acid composition or other circulating factors will be evaluated.
Time frame: 4 years
Association between changes in BAT activity, transcriptional BAT markers and alterations in the gut microbiota profile or bile acid composition
Linear regression analyses will be performed to determine any association between BAT activity or molecular signature and changes in the gut microbiota or bile acids
Time frame: 4 years
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