This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine. The hypothesis is that menthol and the other experimental flavor will interact with nicotine dose to improve taste and liking for e-cigarettes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
56
Participants will receive low dose nicotine (6 mg/ml) or high dose nicotine (12 mg/ml)
Experimental fruit flavored e-cigarette for lab session
Menthol flavored e-cigarette for lab session
CMHC, Substance Abuse Center
New Haven, Connecticut, United States
Change score in Liking/wanting of the e-cigarette
The Drug Effects Questionnaire (Soria et al) will be used to ask about liking and wanting during the lab session
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Change score in rating of coolness
gMLS rating of e-cigarette coolness
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Change score in rating of harshness/irritation
gMLS rating of e-cigarette harshness/irritation
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Change score in rating of sweetness
gMLS rating of e-cigarette sweetness
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Change score in rating of sourness
gMLS rating of e-cigarette sourness
Time frame: End of lab session (+40 minutes)
Change score in rating of fruitiness
gMLS rating of e-cigarette fruitiness
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Change score in rating of total sensation
gMLS rating of e-cigarette total sensation
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
E-cigarette value
Value of e-cigarette as determined by the Multiple Choice Questionnaire (MCP) task
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Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)
Number of puffs
Number of puffs taken at the end of the ad-lib vaping period
Time frame: End of ad-lib lab session 4 (+40 minutes)
Change score in Tobacco Craving
The Brief Questionnaire on Smoking Urges (Tiffany \& Drobes,1991) will be used to assess the magnitude of change in tobacco craving during the lab session
Time frame: Baseline (+10 minutes) to end of lab session (+40 minutes)