Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

Yale University56 enrolled

Overview

This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine. The hypothesis is that menthol and the other experimental flavor will interact with nicotine dose to improve taste and liking for e-cigarettes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Nicotine Dependence

Interventions

NicotineDRUG

Participants will receive low dose nicotine (6 mg/ml) or high dose nicotine (12 mg/ml)

Experimental FlavorOTHER

Experimental fruit flavored e-cigarette for lab session

Menthol FlavorOTHER

Menthol flavored e-cigarette for lab session

Eligibility

Sex: ALLMin age: 18 YearsMax age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 18-20 years * Able to read and write * Urine cotinine levels of \>250 ng/ml at screening appointment * Use of e-cigarettes in the past month * May or may not currently smoke traditional cigarettes Exclusion Criteria: * Seeking smoking cessation treatment * Current/lifetime criteria for dependence on another psychoactive substance -Daily use of alcohol or marijuana or use of any other drugs including cocaine, opiates, stimulants * Regular use of psychoactive drugs including anxiolytics, antidepressants and other psychostimulants * Current or past history of psychosis or other psychiatric diagnosis such as major depression * Any significant current medical condition

Locations (1)

CMHC, Substance Abuse Center

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

Change score in Liking/wanting of the e-cigarette

The Drug Effects Questionnaire (Soria et al) will be used to ask about liking and wanting during the lab session