Quantification of Fetal Brains' Sulci Along Gestation

Rambam Health Care Campus150 enrolled

Overview

Gyrogenesis is an ontogenic process that transforms the smooth (lissencephalic) cortex toward its mature, convolved (gyrencephalic) state. A tortuous, branching and deepening pattern of sulci and fissures outlines for a well-developed cortex. The aim of this study is to find an algorithm that can detect the sulci in ultrasound images of fetus' brain and measure the length of it. This algorithm can be used for research demands like learning the development of the brain from embryo stages until the birth of the baby

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Fetal Brain Injury

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women between the ages of 18-35 * Gestational age between 25-40 weeks * Low risk pregnancies Exclusion Criteria: * Multiple gestation * Fetal brain abnormality

Locations (1)

Rambam Health Care Campus

Haifa, Israel

Outcomes

Primary Outcomes

morphological changes of the developing fetal brain

Ultrasound measurements of the fetal brain sulcation by a computerized algorithm

Time frame: 9 months

Data from ClinicalTrials.gov

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