The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia

Assiut University50 enrolled

Overview

Autoimmune thrombocytopenic purpura is an immunological disorder characterized by increased platelet destruction due to presence of anti-platelet antibodies. Hepatitis C virus infection, which is one of the most common chronic viral infections worldwide, may cause secondary chronic immune thrombocytopenic purpura. It seemed to play a pathogenic role in autoimmune thrombocytopenic purpura. Moreover, the successful response (negative hepatitis C virus - ribonucleic acid) to tapered steroids and antiviral therapy was useful to revert thrombocytopenia

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hepatitis C

Interventions

sofosbuvir daclatasvirDRUG

oral tablets

Ledipasvir/sofosbuvirDRUG

oral tablets

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Hepatitis C virus infection and thrombocytopenia before treatment Exclusion Criteria: * Infection Hepatitis B virus * Hypersplenism * Diseases affecting Bone marrow * Major clotting factors abnormalities eg. Disseminated intravascular coagulopathy, severe Prothrombin deficiency

Locations (1)

Assiut University

Asyut, Egypt

RECRUITING

Outcomes

Primary Outcomes

the mean difference on the platelet count

Time frame: 6 month

Data from ClinicalTrials.gov

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